Profile
Mary Wheldon
My CV
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Education:
Beech Junior and Infant School
Salendine Nook High School (GCSEs)
Greenhead College (A-levels)
University of York (MChem and PhD) -
Qualifications:
Salendine Nook High School 7 A*, 3 A, 2B (English B, Maths A*, Science A*)
I did graphic design and art at school and really enjoyed the creative side to these subjects, really different from Science and Maths. I didn’t really enjoy writing subjects, so I didn’t take history at GCSE
Greenhead College A levels – Biology A, Chemistry A, Physics A, Maths A, general studies B (I didn’t like the essay writing that we did in general studies, I wasn’t great at it!) I enjoyed the range of science at A-level as I didn’t know what I wanted to do when I first went to college, its here I got in to chemistry!
University of York – MChem degree with a year in industry
I spent 1 year working at a company in London as part of my degree, this is where I found out I liked making medicines and that I wanted to do that for my career. I found some aspects of chemistry hard (Physical and Inorganic) but it was a really good degree where we could pick areas that interested us.
University of York – PhD – I went back to York after my year in industry to complete my PhD, I was interested in the research there, and I love the city! My PhD was hard, but I made some amazing friends and learnt so much! -
Work History:
– Musician in a string quartet (I played at weddings and events) while at college
– Postdoctoral Research Fellow at University College London
– Medicinal Chemist at University of Dundee -
Current Job:
Medicinal Chemist at the University of Dundee – working in the Innovative Targets Portfolio. I started work in February 2018
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About Me:
I’m a medicinal chemist at the University of Dundee. I’m originally from Yorkshire, love vintage fashion, and sewing!
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I live in Dundee with my boyfriend. We have a new Labrador puppy called Mavis, and two Guinea Pigs called Links and Lorne! I’m originally from West Yorkshire, but I love living in Scotland and have lived here for 3 years now. I love vintage clothes and make my own dresses in my spare time. I also have a vast collection of earrings – I must have about 100 pairs now! I follow the Formula 1, and have been to 3 races across the world. I love travelling and exploring new places, I’ve been as far as Australia which was amazing! And everywhere I go, I try and have an ice cream, I’ve even got a hashtag! #icecreamsaroundtheworld I play the Violin and play in the Dundee Symphony Orchestra which is great fun! My pronouns are she/her
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I work in a small team of people that include other chemists, biologists and other scientists. We all work together to try and find new medicines to cure different diseases. As a medicinal chemist, this involves me coming up with lots of ideas to make new medicines using lots of different bits of information. I then use synthetic organic chemistry to make these molecules. We can then get the biologist to test them to see if they work, and we use this information to help us make the what we make better. I really enjoy the problem solving aspect of medicinal chemistry, its really exciting when you get a break through and make something that works!
I work mostly in a chemistry lab, where I work in a fumehood to keep us safe. There are lots of other chemists around in the lab, so its really sociable. Generally I spend most of my day putting reactions on and then getting them clean, we have to make sure we have clean material to give to the biologist. I use lots of different machines to help with this, which mean I can do lots of different things at once! I record all the details of my experiments so that we have a record in case anyone else needs to repeat what I’ve done in the future. My job is basically like cooking, I just don’t get to eat what I’ve made!!
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My Typical Day:
I start work at about 8.45 each day (I’m not an early morning person!), I normally check my emails, and then head in to the lab to check on my experiments. If they have worked then I try and get the product out of my experiment mixture. I would normally put two or three experiments on a day, so I would repeat this with all the others. Towards the end of the day I can put more experiments on, ready for the next day, when we do it all again!
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I start work at about 8.45 each day (I’m not an early morning person!). I would then head in to the lab, to check on the experiments I had put on the day before. We use a magnetic stirrer hotplate to heat and stir our reactions. Its like a fancy hob really, and it means we don’t have to manually stir our reactions. I use a machine called an LCMS to look at my reaction to see if its worked. If it has, great! I would then normally try and get the product out of the reaction mixture. We normally do our reactions in a liquid, or solvent, we don’t want this at the end as we like to try and make white solids. So often I will use a rotary evaporator to remove the solvent. This machine has a vacuum which lowers the boiling point of the liquid and makes it easier to get rid of. Once we have a solid, its not normally clean, so I have to clean, or purify, it. To do this we use a technique called column chromatography. This uses the difference in time taken for different molecules to move through a column. This is similar to when you dot black ink on to a bit of paper and put the end in water, the different colours separate out because they move up the paper at a different speed. We can then collect our clean product and using the rotary evaporator again remove the liquid (solvent). I can check if I’ve made the right thing using an NMR machine, this is like a MRI scanner that you get in hospitals but instead of looking at people it looks at tiny molecules. If we have made the right thing we can give it to the biologist to test or we can do another experiment on it. Often we have to do lots of little reactions to make one medicine molecule. I put my experiments on at the end of the day, this involves weighing solids, and measuring out liquids. Then I can check they are safe and leave them to work overnight, so I’m even doing chemistry while I’m sleeping!
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What I'd do with the prize money:
I’d like to organise a community talk, in a cafe or a pub, with lots of different researchers talking about their work, and let everyone come along and ask them questions!
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My Interview
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How would you describe yourself in 3 words?
Ice-cream-loving medicine maker!
What did you want to be after you left school?
Pathologist
Were you ever in trouble at school?
Not really!
Who is your favourite singer or band?
Queen
What's your favourite food?
Yorkshire Puddings!
If you had 3 wishes for yourself what would they be? - be honest!
Make a medicine that saves peoples lives, have enough money to travel the world, for all my family and friends to be happy and healthy!
Tell us a joke.
What did the cheese say to itself in the mirror? Halloumi!
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